Livedoid vasculitis
Livedoid vasculitis ئاستا خاراكتېرلىك دانىخورەك كېسىلى بولۇپ ، ئاساسلىقى ياش ۋە ئوتتۇرا ياشلىق ئاياللاردا كۆرۈلىدۇ. ئۇنىڭ ئالاھىدىلىكىنى تەسۋىرلەشتە قوللىنىلغان بىر قىسقارتىلما «تۆۋەنكى پۇتنىڭ كۆرۈش تور پەردىسى ئاغرىق خاراكتېرلىك كۆكرەك يارىسى» (PURPLE). ئۇ سوزۇلما خاراكتېرلىك ۋېنا يۇقىرى قان بېسىمى ۋە ۋاراڭ-چۇرۇڭ قاتارلىق بىر قاتار كېسەللىكلەر بىلەن مۇناسىۋەتلىك.
☆ گېرمانىيەدىن كەلگەن 2022-يىلدىكى Stiftung Warentest نەتىجىسىدە ، ئىستېمالچىلارنىڭ ModelDerm غا بولغان رازىمەنلىكى ھەقلىق يىراقتىن داۋالاش مەسلىھەتچىلىكىدىن سەل تۆۋەن بولدى.
ئازاب بىلەن بىللە بولىدۇ.
References
Livedoid vasculopathy ئاز ئۇچرايدىغان تېرە كېسەللىكلىرى بولۇپ ، تۆۋەنكى پۇتىغا قايتىپ كېلىدۇ.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy كەم ئۇچرايدىغان تېرە كېسەللىكلىرى بولۇپ ، تۆۋەنكى پۇتنىڭ قايتا-قايتا يارا پەيدا قىلىشىنى كەلتۈرۈپ چىقىرىدۇ. ئېنىق سەۋەبى تېخى ئېنىق بولمىسىمۇ ، قاننىڭ ئۇيۇلۇشى (hypercoagulability) ئاساسلىق ئامىل دەپ قارىلىدۇ ، ياللۇغ ئىككىنچى ئورۇندا تۇرىدۇ. كىيىم كىيىشكە تۆھپە قوشىدىغان ئامىللار تۆۋەندىكىچە - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. بىئوپوسسىيەدە ، بۇ ئەھۋال تومۇر ئىچىدىكى قان نوكچىسى ، تومۇر دىۋارىنىڭ قېلىنلىشىشى ۋە جاراھەت ئىزلىرىنى كۆرسىتىدۇ. داۋالاش قان پلاستىنكىسىغا قارشى دورىلار ، قان تازىلاش ماشىنىسى ۋە تالالىق داۋالاش قاتارلىق دورىلار بىلەن قان نوكچىسى ئالدىنى ئېلىشنى ئاساس قىلغان كۆپ تەرەپلىمىلىك ئۇسۇلنى ئۆز ئىچىگە ئالىدۇ. بۇ تېرە كېسەللىكلىرى ئۈچۈن ھەر خىل دورىلارنى ئىشلىتىشكە بولىدۇ - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy ئىككى پۇتىدا جاراھەت كۆرۈلىدىغان ئاز ئۇچرايدىغان ئەھۋال. كىچىك قان تومۇرلاردا قان نوكچىسى شەكىللىنىش قان تومۇرنىڭ بۇزۇلۇشى بىلەن بىللە ، ئۇيۇلۇشنىڭ كۆپىيىشى ۋە ئۇيۇلنىڭ پارچىلىنىشىنى كەلتۈرۈپ چىقىرىدۇ دەپ قارىلىدۇ. بۇ ئاياللاردا كۆپ ئۇچرايدۇ ، بولۇپمۇ 15 ياشتىن 50 ياشقىچە. تاماكا تاشلاش ، جاراھەتنى ئاسراش ۋە قان تازىلاش دورىسى ۋە ئانتىتېلاغا قارشى دورىلار قاتارلىق دورىلارنى ئىشلىتىش ئۈنۈملۈك بولدى.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
